Open AccessEffect of microgravity on the mesenchymal stem cell characteristics of limbal fibroblasts
Author(s) -
Shu-I Pao,
KeHung Chien,
HsiangJu Lin,
MingCheng Tai,
JiannTorng Chen,
Chang-Min Liang
Publication year - 2017
Publication title -
journal of the chinese medical association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.535
H-Index - 42
eISSN - 1728-7731
pISSN - 1726-4901
DOI - 10.1016/j.jcma.2017.01.008
Subject(s) - cd90 , mesenchymal stem cell , stem cell , limbal stem cell , medicine , flow cytometry , cd44 , microbiology and biotechnology , andrology , cell , pathology , immunology , cd34 , chemistry , biology , corneal epithelium , epithelium , biochemistry
Mesenchymal stem cells (MSCs) are important for regenerative medicine. Limbal fibroblasts (LFs), present in the corneal limbus, have been shown to possess MSC characteristics, and can differentiate into other cell types. The current study sought to investigate the effect of microgravity on the proliferation and differentiation of LFs, and identify culture conditions to obtain a high proportion of LFs possessing MSC characteristics.