Open AccessN-Acetyl cysteine protects diabetic mouse derived mesenchymal stem cells from hydrogen-peroxide-induced injury: A novel hypothesis for autologous stem cell transplantation
Author(s) -
Fatima Ali,
Mohsin Khan,
Shaheen N. Khan,
Sheikh Riazuddin
Publication year - 2016
Publication title -
journal of the chinese medical association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.535
H-Index - 42
eISSN - 1728-7731
pISSN - 1726-4901
DOI - 10.1016/j.jcma.2015.09.005
Subject(s) - medicine , mesenchymal stem cell , hydrogen peroxide , transplantation , cysteine , stem cell , microbiology and biotechnology , cancer research , immunology , biochemistry , pathology , surgery , enzyme , biology
Stem cell transplantation is one of the therapeutic options available to repair damaged organs. However, transplanted cells entail several challenges including their survival in diabetes-affected injured tissue. This study was designed to determine the effects of preconditioning of mesenchymal stem cells (MSCs) with N-acetyl cysteine (NAC), a widely used antioxidant drug.