N-Acetyl cysteine protects diabetic mouse derived mesenchymal stem cells from hydrogen-peroxide-induced injury: A novel hypothesis for autologous stem cell transplantation | Zendy

Fatima Ali | Zendy; Mohsin Khan | Zendy; Shaheen N. Khan | Zendy; Sheikh Riazuddin | Zendy

Open Access

N-Acetyl cysteine protects diabetic mouse derived mesenchymal stem cells from hydrogen-peroxide-induced injury: A novel hypothesis for autologous stem cell transplantation

Author(s) -

Fatima Ali,

Mohsin Khan,

Shaheen N. Khan,

Sheikh Riazuddin

Publication year - 2016

Publication title -

journal of the chinese medical association

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.535

H-Index - 42

eISSN - 1728-7731

pISSN - 1726-4901

DOI - 10.1016/j.jcma.2015.09.005

Subject(s) - oxidative stress , medicine , mesenchymal stem cell , superoxide dismutase , catalase , malondialdehyde , transplantation , stem cell , pharmacology , viability assay , lactate dehydrogenase , stem cell therapy , apoptosis , microbiology and biotechnology , biochemistry , chemistry , biology , pathology , enzyme

Stem cell transplantation is one of the therapeutic options available to repair damaged organs. However, transplanted cells entail several challenges including their survival in diabetes-affected injured tissue. This study was designed to determine the effects of preconditioning of mesenchymal stem cells (MSCs) with N-acetyl cysteine (NAC), a widely used antioxidant drug.

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