Open AccessAssociation of polymorphisms of adiponectin gene promoter-11377C/G, glutathione peroxidase-1 gene C594T, and cigarette smoking in nonalcoholic fatty liver disease
Author(s) -
Chaoxian Zhang,
Like Guo,
Yong-Mei Qin,
Guangyan Li
Publication year - 2016
Publication title -
journal of the chinese medical association
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.535
H-Index - 42
eISSN - 1728-7731
pISSN - 1726-4901
DOI - 10.1016/j.jcma.2015.09.003
Subject(s) - adiponectin , nonalcoholic fatty liver disease , medicine , fatty liver , genotype , population , glutathione peroxidase , endocrinology , gastroenterology , gene , genetics , disease , biology , insulin resistance , oxidative stress , obesity , catalase , environmental health
The number of studies on adiponectin, GPx-1 gene polymorphisms, and nonalcoholic fatty liver disease (NAFLD) susceptibility is increasing, but none have investigated the effect of cigarette smoking in combination with the gene polymorphisms on the susceptibility to NAFLD. In order to understand the distribution of adiponectin and GPx-1 in the local population, to explore the possible association of cigarette smoking with adiponectin and GPx-1 gene polymorphisms in the pathogenesis of NAFLD, we conducted this research, examining the distribution of polymorphisms of adiponectin and GPx-1 in NAFLD patients and healthy controls, analyzing the association between these polymorphisms and cigarette smoking.