Open AccessThe Combined Roles of Nonsomatic Depressive Symptomatology, Neurocognitive Function, and Current Substance Use in Medication Adherence in Adults Living With HIV Infection
Author(s) -
Travis M Scott,
Desiree Byrd,
Miguel Arce Rentería,
Kelly Coulehan,
Caitlin Miranda,
Armando Fuentes,
Monica Rivera Mindt
Publication year - 2018
Publication title -
the journal of the association of nurses in aids care/journal of the association of nurses in aids care
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.636
H-Index - 49
eISSN - 1552-6917
pISSN - 1055-3290
DOI - 10.1016/j.jana.2017.08.002
Subject(s) - neurocognitive , medicine , cart , human immunodeficiency virus (hiv) , depression (economics) , clinical psychology , depressive symptoms , psychiatry , medication adherence , substance use , cognition , family medicine , mechanical engineering , engineering , economics , macroeconomics
Depression, global neurocognitive (GNC) function, and substance use disorders (SUDs) are each associated with medication adherence in persons living with HIV (PLWH). Because somatic symptoms can inflate depression scores in PLWH, the role of nonsomatic depressive symptomatology (NSDS) should be considered in adherence. However, the combined roles of NSDS, GNC function, and current SUDs in predicting combined antiretroviral therapy (cART) adherence remain poorly understood. Forty PLWH (70% Latina/o; 30% non-Hispanic White) completed psychiatric/SUD, neurocognitive, and self-report cART adherence evaluations. Higher NSDS was associated with suboptimal adherence (p < .01), but optimal and suboptimal adherers did not differ in GNC function or current SUDs. Only NSDS was associated with suboptimal adherence, after accounting for GNC function and SUDs (p = .01). NSDS uniquely predicted self-reported adherence, beyond GNC function and current SUDs among ethnically diverse PLWH. Methodological issues between present and prior studies should also be considered.