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Incidence of dementia in the oldest‐old and its relationship with age: The Monzino 80‐plus population‐based study
Author(s) -
Lucca Ugo,
Tettamanti Mauro,
Tiraboschi Pietro,
Logroscino Giancarlo,
Landi Cristina,
Sacco Leonardo,
Garrì Mariateresa,
Ammesso Sonia,
Biotti Anna,
Gargantini Elena,
Piedicorcia Alessandro,
Mandelli Sara,
Riva Emma,
Galbussera Alessia A.,
Recchia Angela
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.09.083
Subject(s) - dementia , incidence (geometry) , medicine , demography , population , gerontology , cumulative incidence , pediatrics , disease , environmental health , cohort , physics , sociology , optics
Relationship between age and dementia at extreme old ages is still an open question, yet population‐based studies in this high‐risk age segment are rare. Methods The Monzino 80‐plus is a population‐based study among residents 80 years and older in the Varese province, Italy. Of 1371 eligible individuals, 1294 (94.4%), of whom 64 are centenarians, were included in the incidence study. Results Since 2002, 584 new cases of all‐cause dementia were identified over 15 years. The overall incidence rate was 7.9 per 100 person‐years. Dementia risk rose with age (IRR: 1.06), with the cubic model providing the best fit (R 2 = 0.91–0.96). Cumulative incidences of dementia unadjusted and adjusted for competing mortality risk progressively diverged with age. Conclusion Dementia incidence also keeps rising in nonagenarians and centenarians. Slowing down in growing risk of developing dementia with age is mainly attributable to increasing competing risk of death and resulting selective survival of individuals at lower risk of dementia.