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Synaptic, axonal damage and inflammatory cerebrospinal fluid biomarkers in neurodegenerative dementias
Author(s) -
Antonell Anna,
TortMerino Adrià,
Ríos José,
Balasa Mircea,
BorregoÉcija Sergi,
Auge Josep M.,
MuñozGarcía Cristina,
Bosch Beatriz,
Falgàs Neus,
Rami Lorena,
RamosCampoy Oscar,
Blennow Kaj,
Zetterberg Henrik,
Molinuevo José L.,
Lladó Albert,
SánchezValle Raquel
Publication year - 2020
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.09.001
Subject(s) - neurodegeneration , frontotemporal dementia , cerebrospinal fluid , neurogranin , neuroinflammation , medicine , dementia , pathology , disease , neuroscience , psychology , biology , genetics , phosphorylation , protein kinase c
Synaptic damage, axonal neurodegeneration, and neuroinflammation are common features in Alzheimer's disease (AD), frontotemporal dementia (FTD), and Creutzfeldt‐Jakob disease (CJD). Methods Unicentric cohort of 353 participants included healthy control (HC) subjects, AD continuum stages, genetic AD and FTD, and FTD and CJD. We measured cerebrospinal fluid neurofilament light (NF‐L), neurogranin (Ng), 14‐3‐3, and YKL‐40 proteins. Results Biomarkers showed differences in HC subjects versus AD, FTD, and CJD. Disease groups differed between them except AD versus FTD for YKL‐40. Only NF‐L differed between all stages within the AD continuum. AD and FTD symptomatic mutation carriers presented differences with respect to HC subjects. Applying the AT(N) system, 96% subjects were positive for neurodegeneration if 14‐3‐3 was used, 94% if NF‐L was used, 62% if Ng was used, and 53% if YKL‐40 was used. Discussion Biomarkers of synapse and neurodegeneration differentiate HC subjects from neurodegenerative dementias and between AD, FTD, and CJD. NF‐L and 14‐3‐3 performed similar to total tau when AT(N) system was applied.