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P4‐632: BASELINE COMPOSITION OF MACRONUTRIENTS IS ASSOCIATED WITH RISK OF MILD COGNITIVE IMPAIRMENT OR DEMENTIA: RESULTS FROM THE WOMEN'S HEALTH INITIATIVE MEMORY STUDY (WHIMS)
Author(s) -
Leng Xiaoyan Iris,
Payne Martha E.,
Rapp Stephen R.,
Vitolins Mara
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.08.181
Subject(s) - dementia , hazard ratio , medicine , lower risk , polyunsaturated fatty acid , saturated fat , cognitive decline , gerontology , diabetes mellitus , endocrinology , fatty acid , chemistry , cholesterol , biochemistry , disease , confidence interval
PiB SUVR, and AV-1451 SUVR in regions associated with Braak Stages 1/2, 3/4, and 5/6 using linear regression with adjustment for age, sex, and education. Results: In comparison to Abparticipants (n1⁄452, 59.1% of total sample), Ab+ participants (n1⁄436, 40.9% of total sample) were older (79.6 years vs 77.0 years; F1⁄44.08, p1⁄4.046), had a higher proportion of APOE*4 carriers (39.1% vs 8.6%; c1⁄47.90, p1⁄4.008), andwere marginally less likely to be college educated (50.0% vs 67.3%; c1⁄42.66, p1⁄4.103). Global PiB retention was positively correlated with AV-1451 retention in Braak-associated regions 1/2 (r1⁄4.338, p1⁄4.001), 3/4 (r1⁄4.440, p<.001), and 5/6 (r1⁄4.403, p<.001). Regarding neuropsychological test performance, higher amyloid, but not tau, was associated with worse performance on a 20-Minute Delayed Recall Word List (b1⁄4 3.01, SE1⁄41.33, p1⁄4.027) and the Indiana University Token Test (b1⁄4-0.73, SE1⁄40.32 p1⁄4.027). Conclusions: Our populationbased findings are broadly consistent with clinic-based neuroimaging studies relating cognition, demographics, and APOE*4 to Ab and tau deposition cross-sectionally. Future analysis will investigate long-term predictors of Ab and tau deposition from the parent MYHAT study.