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P4‐599: ANTE‐MORTEM BINDING OF 18 F‐THK5317 PET IN A CASE OF FTLD AND POST‐MORTEM COMPARISON OF TAU BINDING USING 3 H‐THK5117 AND 3 H‐MK6240
Author(s) -
Lemoine Laetitia,
Chiotis Konstantinos,
Leuzy Antoine,
Nennesmo Inger,
Nordberg Agneta K.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.08.147
Subject(s) - frontotemporal lobar degeneration , corticobasal degeneration , pathology , autopsy , temporal cortex , cortex (anatomy) , nuclear medicine , immunostaining , frontotemporal dementia , medicine , immunohistochemistry , dementia , atrophy , neuroscience , psychology , progressive supranuclear palsy , disease
The developed models were able to consistently identify several brain regions as significant predictors of conversion. Significant predictors in the model include right hippocampus (p < .001), left entorhinal cortex (p 1⁄4 .008), left isthmus of cingulate gyrus (p 1⁄4 .011), left precuneus (p 1⁄4 .058), and right medial temporal lobe (p 1⁄4.028). Additionally, independent of FDG-PET, Apoe-4 status remained a significant predictor in the model (p1⁄4 .017).Conclusions: The presented models identify key features in the prediction of progression from MCI to AD. These regions align with known regions important to AD and extend to show significant predictive ability of deficiencies in brain glucose metabolism.