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P4‐590: DEEP OCCIPITAL WHITE MATTER HYPERINTENSITIES ARE ROBUSTLY RELATED TO AMYLOID PATHOLOGY AND MAY BE AN EARLY MARKER FOR ALZHEIMER'S DISEASE
Author(s) -
Pålhaugen Lene,
Selnes Per,
Sudre Carole H.,
Tecelao Sandra,
Bjornerud Atle,
Fladby Tormod
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.08.138
Subject(s) - dementia , asymptomatic , cardiology , hyperintensity , medicine , white matter , cerebral amyloid angiopathy , pathology , disease , audiology , magnetic resonance imaging , radiology
signature (derived using FreeSurfer), hippocampal volume (derived using FIRST), and global atrophy (ratio of intracranial CSF volume to brain tissue volume, derived using SPM12). Results: The three MRI-based measures of (N) and CSF NfL showed similar associations with AD continuum group (i.e., Kruskal-Wallis ps<.001), with relatively larger effect sizes when comparing the CU A-Tto the MCI A+ (Cliff’s deltas .741) and AD A+ groups (Cliff’s deltas .810) than to the A+TCU (Cliff’s deltas 1⁄4 .112-.298) and A+T+ CU groups (Cliff’s deltas 1⁄4 .212-.731). See Table 2 and Figure 1. Conclusions: These findings suggest that the three MRI-based morphometric estimates and CSF NfL similarly differentiate individuals across the AD continuum on (N) status. In many applications, a simple estimate of global atrophy or CSF NfL may be preferred as a marker of (N) across the AD continuum given the methodological robustness and ease of calculation of these measures when compared to hippocampal volume or a cortical-thickness AD signature. P4-590 DEEP OCCIPITALWHITE MATTER HYPERINTENSITIES ARE ROBUSTLY RELATED TOAMYLOID PATHOLOGYAND MAY BE AN EARLY MARKER FOR ALZHEIMER’S DISEASE