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P4‐586: CLINICAL CHARACTERIZATION OF [ 18 F]PM‐PBB3 IN THE BRAINS OF MILD‐REPETITIVE TRAUMATIC BRAIN INJURY
Author(s) -
Takahata Keisuke,
Sahara Naruhiko,
Shimada Hitoshi,
Tagai Kenji,
Kubota Manabu,
Takado Yuhei,
Seki Chie,
Sano Yasunori,
Yamamoto Yasuharu,
Kuramochi Shin,
Mizushima Jin,
Anamizu Sachiko,
Tabuchi Hajime,
Kawamura Kazunori,
Zhang Ming-Rong,
Mimura Masaru,
Higuchi Makoto
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.08.134
Subject(s) - traumatic brain injury , neurocognitive , concussion , white matter , medicine , cognitive impairment , cognition , psychiatry , magnetic resonance imaging , radiology , disease , poison control , injury prevention , environmental health
Background: Aging is often characterized by cognitive decline across the adult lifespan. Yet there is substantial variability in cognitive aging trajectories, with some individuals showing minimal decline and some showing rapid decline. The current study aims to identify successful agers who resist age-related decline in the Dallas Lifespan Brain Study, and compare the brain activity between successful and unsuccessful agers. Methods: A total of 232 participants aged 35-89 years old at baseline completed two waves of longitudinal memory measurement with a four-year interval, as well as a subsequent memory fMRI task in the second wave of testing. Participants’ cross-sectional performance level and longitudinal cognitive change in episodic memory were estimated using latent difference score model. Then, participants were divided into three age groups (Middle: 35-54; young-old: 55-69; oldold: 70-89), and successful agers were defined as individuals with better than average performance level and slower than average change rate in the age group, vice versa for unsuccessful agers. The brain activity of subsequent memory effect (high-confidence remember > forget) in task-related regions was compared between successful and unsuccessful agers. Results: A total of 90 unsuccessful agers and 95 successful agers were identified. In the subsequent memory fMRI task, participants overall activated bilateral fusiform/parahippocampal areas and bilateral middle occipital regions during encoding of successfully remembered items. ROI analyses using these clusters found that successful memory aging in young-old individuals was related to preserved activation in these temporal-occipital regions, particularly in the right middle occipital cluster and the left fusiform/parahippocampal cluster. Conclusions: Youngold individuals may rely on the ability to maintain brain function, despite aging, to achieve successful cognitive aging. Old-old adults, on the other hand, barely had any task-related activity suggesting the limited brain maintenance in those aged brains. Future study may explore longitudinal change in functional activation and directly track the brain functional development in successful and unsuccessful agers.