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P4‐575: ARTERIAL STIFFNESS IS ASSOCIATED WITH GREATER WHITE MATTER BLOOD FLOW AND WHITE MATTER HYPERINTENSITIES REGARDLESS OF COGNITIVE STATUS
Author(s) -
Jung Youngkyoo,
Hughes Timothy M.,
Lockhart Samuel,
Kim Donghoon,
Whitlow Christopher T.,
Craft Suzanne
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.08.123
Subject(s) - arterial stiffness , pulse wave velocity , cardiology , hyperintensity , white matter , medicine , cerebral blood flow , supine position , magnetic resonance imaging , nuclear medicine , blood pressure , radiology
within some brain regions vulnerable to AD such as the medial temporal or the inferior parietal cortices. Conclusions: To the best of our knowledge, this is the first MEG neuroimaging-genetic approach within an elderly population that considers the possible association of a GRS for AD on brain neurophysiological activity. This, in turn, could participate as an early biomarker of synaptic neuronal damage before clinical symptomatology becomes manifest.