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DT‐01‐06: ASSOCIATION OF APOE E2 GENOTYPE WITH NEUROPROTECTION: A TRANS‐DIAGNOSTIC STUDY OF 1557 BRAINS IN THE NACC V 10 DATA BASE
Author(s) -
Goldberg Terry E.,
Devanand Davangere P.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.08.009
Subject(s) - apolipoprotein e , cerebral amyloid angiopathy , medicine , neuroprotection , pathological , disease , frontotemporal dementia , dementia , pathology , neuroscience , oncology , psychology
tau early in the course of AD. Et SUVrs were elevated in a cohort of subjects that had normal signal on a global posterior neocortical VOI (MUBADA). These subjects had more tau accumulation, greater neurodegeneration, and higher cognitive deterioration at 18 months compared to subjects with normal Et SUVr. Here, we apply the Et VOI to an autopsy cohort to evaluate associations with intermediate (B2; Braak III or IV) NFT pathology. Methods: 67 subjects from a phase III autopsy study (Table 1) underwent ante-mortem flortaucipir PET imaging. Two experts recorded neuropathological findings according to NIA-AA recommendations. Flortaucipir images were visually read [Arora, HAI 2019] as tAD-, tAD+, or tAD++ based on neocortical tracer activity (Table 2). MUBADA and Et SUVrs were calculated and cutoffs derived from themean + 2.5SD of young cognitively normal controls were applied to classify subjects for comparison to pathological findings.Results: As shown in Figure 1, 35 of 38 B3 subjects vs. only 3 of 15 B2 subjects that went to autopsy and had quantifiable scans were identified as tAD+/tAD++ on visual interpretation. In contrast, Et SUVr was above threshold in 12 of 15 B2 subjects, including 10 of 11 classified as Braak IV (Figure 1A). Both measures correctly classified 6 of 7 subjects with B1 pathology as tau negative. MUBADA failed to discriminate subjects with B2 vs. B1 pathology (Figure 1B). Conclusions: In a limitedsize autopsy dataset, Et SUVr improved sensitivity to intermediate (B2), and particularly Braak IV pathology, compared to visual reads and global quantitative measures. The use of Et SUVr quantitation as an adjunct to visual interpretation may improve the diagnostic power of flortaucipir compared to visual interpretation alone. Additional research refining the Et VOI to mitigate the effects of atrophy may further improve performance. DT-01-06 ASSOCIATION OFAPOE E2 GENOTYPE WITH NEUROPROTECTION: ATRANSDIAGNOSTIC STUDY OF 1557 BRAINS IN THE NACC V 10 DATA BASE Terry E. Goldberg and Davangere P. Devanand, Columbia University Medical Center, New York, NY, USA; Columbia University, College of Physicians and Surgeons, New York, NY, USA. Contact e-mail: teg2117@ cumc.columbia.edu