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Local ancestry at APOE modifies Alzheimer's disease risk in Caribbean Hispanics
Author(s) -
Blue Elizabeth E.,
Horimoto Andréa R.V.R.,
Mukherjee Shubhabrata,
Wijsman Ellen M.,
Thornton Timothy A.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.07.016
Subject(s) - apolipoprotein e , logistic regression , odds ratio , demography , genotype , disease , genetic genealogy , odds , genome wide association study , gerontology , medicine , genetics , biology , single nucleotide polymorphism , population , gene , sociology
Although the relationship between APOE and Alzheimer's disease (AD) is well established in populations of European descent, the effects of APOE and ancestry on AD risk in diverse populations is not well understood. Methods Logistic mixed model regression and survival analyses were performed in a sample of 3067 Caribbean Hispanics and 3028 individuals of European descent to assess the effects of APOE genotype, local ancestry, and genome‐wide ancestry on AD risk and age at onset. Results Among the Caribbean Hispanics, individuals with African‐derived ancestry at APOE had 39% lower odds of AD than individuals with European‐derived APOE , after adjusting for APOE genotype, age, and genome‐wide ancestry. While APOE E2 and E4 effects on AD risk and age at onset were significant in the Caribbean Hispanics, they were substantially attenuated compared with those in European ancestry individuals. Discussion These results suggest that additional genetic variation in the APOE region influences AD risk beyond APOE E2/E3/E4.