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Current and past leisure time physical activity in relation to risk of Alzheimer's disease in older adults
Author(s) -
Ogino Erika,
Manly Jennifer J.,
Schupf Nicole,
Mayeux Richard,
Gu Yian
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.07.013
Subject(s) - hazard ratio , confidence interval , proportional hazards model , gerontology , medicine , demography , lower risk , incidence (geometry) , mathematics , geometry , sociology
The associations between self‐reported current and past leisure time physical activity (LTPA) and Alzheimer's disease (AD) incidence were determined using data from the multiethnic Washington/Hamilton Heights‐Inwood Columbia Aging Project (WHICAP) study. Methods The metabolic equivalent of LTPA energy expenditure was calculated for self‐reported current and past LTPA for 1345 older adults. A Cox proportional hazard model was conducted to estimate the association between LTPA (low, middle, and high) and incident AD risk. Results Comparing high to low level, current and past LTPA were both associated with reduced AD risk, with hazard ratio (95% confidence interval) = 0.39 (0.20–0.75) and 0.37 (0.18–0.75), respectively. Compared with “always low,” “increased” and “always high” LTPA throughout life were associated with reduced AD risk, with hazard ratio (95% confidence interval) = 0.60 (0.36–0.99) and 0.28 (0.08–0.94), respectively. Light‐ and moderate‐intensity LTPA were associated with lower AD risk. Discussion LTPA both throughout life and later in life are associated with lower risk of AD.