Premium
Comparison of variables associated with cerebrospinal fluid neurofilament, total‐tau, and neurogranin
Author(s) -
Mielke Michelle M.,
Syrjanen Jeremy A.,
Blennow Kaj,
Zetterberg Henrik,
Skoog Ingmar,
Vemuri Prashanthi,
Machulda Mary M.,
GraffRadford Jonathan,
Knopman David S.,
Jack Clifford R.,
Petersen Ronald C.,
Kern Silke
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.07.009
Subject(s) - neurogranin , cerebrospinal fluid , neurodegeneration , psychology , medicine , pathology , oncology , biology , disease , genetics , signal transduction , protein kinase c
Three cerebrospinal fluid (CSF) markers of neurodegeneration (N) (neurofilament light [NfL], total‐tau [T‐tau], and neurogranin [Ng]) have been proposed under the AT(N) scheme of the National Institute on Aging–Alzheimer's Association Research Framework. Methods We examined, in a community‐based population (N = 777, aged 50–95) (1) what variables were associated with each of the CSF (N) markers, and (2) whether the variables associated with each marker differed by increased brain amyloid. CSF T‐tau was measured with an automated electrochemiluminescence Elecsys immunoassay; NfL and Ng were measured with in‐house enzyme‐linked immunosorbent assays. Results Multiple variables were differentially associated with CSF NfL and T‐tau levels, but not Ng. Most associations were attenuated after adjustment for age and sex. T‐tau had the strongest association with cognition in the presence of amyloidosis, followed by Ng. Variables associations with NfL did not differ by amyloid status. Discussion Understanding factors that influence CSF (N) markers will assist in the interpretation and utility of these markers in clinical practice.