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P1‐358: ALZHEIMER'S RELATED ALTERED MICROSTRUCTURE INTEGRITY IN DOWN SYNDROME
Author(s) -
Rosas H. Diana,
Mercaldo Nathaniel,
Hsu Eugene,
Brickman Adam M.,
Pulsifer Margaret,
Pang Deborah,
Jordan Courtney,
Doran Eric,
Yassa Michael A.,
Keator David,
Sathishkumar Mithra,
Price Julie C.,
Krinsky-McHale Sharon J.,
Silverman Wayne,
Lott Ira T.,
Schupf Nicole,
Lai Florence
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.913
Subject(s) - fractional anisotropy , diffusion mri , white matter , dementia , inferior longitudinal fasciculus , cardiology , superior longitudinal fasciculus , neuropathology , psychology , corticospinal tract , alzheimer's disease , medicine , neuroscience , pathology , disease , magnetic resonance imaging , radiology
Assessment score (p1⁄4 0.020) and higher prevalence of REM sleep behavior disorder (p 1⁄4 0.018) were also the association factors for OH in DLB. However, visual hallucinations, fluctuating cognition, or parkinsonism were not associated with OH in DLB. Conclusions: Our study shows that DLB patients co-morbid OH is younger, with less severe dementia, and better cognitive performance, these findings are consistent with our recent study on OH in Parkinson’s disease dementia. We considered the reducing blood flow in occipital lobes as a compensation for providing better blood supplies in temporo-parietal association areas. Blood flows of these areas are supplied by the same posterior circulation.