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P1‐353: OCCIPITAL HYPOPERFUSION IN PARKINSON DISEASE DEMENTIA ARE ASSOCIATED WITH BETTER COGNITIVE AND MOTOR FUNCTIONS
Author(s) -
Lin ChingNi
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.908
Subject(s) - dementia with lewy bodies , dementia , parkinson's disease , clinical dementia rating , rating scale , cognition , medicine , perfusion , statistical significance , lewy body , psychology , disease , cardiology , audiology , psychiatry , developmental psychology
for decade of life were classified as having high WMH burden (WMH+). Amyloid-b load was assessed using PET (Ab+ defined as SUVR/BeCKeT 1.4). In participants with 3 assessment timepoints, linear mixed models were used to compare slopes of change in executive function by Ab and WMH status, adjusting for age, sex, and education. Cox proportional hazards analysis was used to investigate the association between WMH/Ab status and risk of progression to MCI/dementia over 8 years, adjusting for demographic and clinical risk factors. Results: A total of 483 participants with baseline WMH volumes were included to derive thresholds of WMH+ by decade of life. Of these, 375 had 3 neuropsychological assessments (mean age 69 years [SD 6.3], 56.1% female, 23.5% ApoE4 carriers, 35.9% Ab+). There were no differences between WMH+ and WMHparticipants in age, sex, education, ApoE4, Ab burden (dichotomised or continuous) or baseline cognitive performance. Ab+ (B1⁄4-0.02, SE1⁄40.009, p<0.05) and WMH+ (B1⁄40.04, SE1⁄40.01, p<0.001) status were both independently and in combination (B1⁄4-0.07, SE1⁄40.02, p<0.001) associated with greater executive function decline. Ab+/WMH+ participants had 7.4x greater risk of transition to MCI/dementia compared to Ab-/ WMH-; Ab+ or WMH+ in isolation were not associated with a significantly increased risk of transition to MCI/dementia. Conclusions: High WMH and Ab burden were independently and jointly associated with decline in executive function, but only the combination was associated with increased risk of transition to MCI/Dementia over 8 years. These results highlight the impact of comorbidity of AD and cerebrovascular disease on clinical outcomes.