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P1‐336: COGNITIVE IMPAIRMENT AND ABNORMAL GAIT CAN HELP TO DIFFERENTIATE CEREBRAL AMYLOID ANGIOPATHY RELATED INFLAMMATION FROM ALZHEIMER'S DISEASE
Author(s) -
Qian Hairong
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.891
Subject(s) - cerebral amyloid angiopathy , fluid attenuated inversion recovery , medicine , hyperintensity , pathology , cerebrospinal fluid , cognitive decline , magnetic resonance imaging , apolipoprotein e , brain biopsy , white matter , disease , dementia , radiology
comparison correction. Additionally, we computed Fisher z-transformed cross-correlation coefficients between all pairs of cognitive networks to study large-scale interactions. Results: The correlation between the posterior default mode network and auditory network was nominally greater in the AD-Executive group compared to the AD-No domain group (Figure 2). Additionally, the correlation between the salience network and the anterior default mode network was greater in the AD-Memory group than in the AD-Executive and AD-No domain groups (Figure 3). Notably, we found no difference in functional connectivity patterns in the hypothesized networks (hippocampal, right/left executive and visual) between subgroups.Conclusions: The default mode network is widely accepted to be affected by AD pathology and normal aging processes. Previous studies have also noted increases in salience network connectivity in AD’s early stages. Our results suggest the AD-memory groupmay be vulnerable to these processes and perhaps driving results in other reports. Though our sample size was small, we reached consistent results by two different methods, establishing exciting groundwork for future investigation. Larger samples will be needed for firm conclusions.