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P1‐335: FUNCTIONAL CONNECTIVITY PATTERNS ACROSS COGNITIVELY‐DEFINED ALZHEIMER'S DISEASE SUBTYPES IN THE ALZHEIMER'S DISEASE NEUROIMAGING INITIATIVE
Author(s) -
Lee Briana E.,
Crane Paul K.,
Risacher Shan L.,
Groot Colin,
Mez Jesse,
Saykin Andrew J.,
Trittschuh Emily H.,
MacDonald Christine,
Ossenkoppele Rik,
Gibbons Laura E.,
Sanders R. Elizabeth,
Choi Seo-Eun,
Mukherjee Shubhabrata,
Sohi Harkirat,
Gennari John,
Madhyastha Tara
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.890
Subject(s) - default mode network , salience (neuroscience) , psychology , cognition , correlation , neuroimaging , alzheimer's disease , audiology , cognitive impairment , disease , neuroscience , medicine , geometry , mathematics
Methods: In this cross-sectional study, 340 participants (90 healthy controls, 132 MCI, 118 AD) underwent cognitive testing, magnetic resonance imaging, andAPOEgenotyping. RegionalWMHvolumes were obtained from FLAIR images, and WMH asymmetry was measured as the difference in normalized hemisphericWMHvolume (WMH/ICV) adjusted for region-specific structural brain asymmetry and total WMH volume (Fig.1). WMH asymmetry was analysed in relation to disease classification, cognitive scores, and APOE4 status using ANCOVA and multiple regression analysis, controlling for gender, age, and ethnicity. Moderation analysis examined interaction effects of APOE4 on the association between cognition and WMH asymmetry. Results: Greater left-dominant WMH asymmetry in the occipital lobe was observed in AD participants, compared to healthy controls and MCI [F(2,171) 1⁄4 4.16, p1⁄4.017], and was associated with poorer MMSE (p1⁄4.009), MoCA (p1⁄4.018), ADAS-Cog Immediate Recall (p1⁄4.021), ADAS-Cog Delayed Word Recall task (p1⁄4.024), the Boston Naming Test (p1⁄4.013), semantic fluency (p1⁄4.008), and Color Trails Test 2 (p1⁄4.041) amongst MCI and AD participants (Fig. 2). Cognitively impaired (MCI and AD) APOE4 carriers had greater left-dominant WMH asymmetry in the whole brain (p1⁄40.38) and frontal lobe (p1⁄40.02), compared to APOE4 non-carriers. Moderation analysis demonstrated that in MCI and AD, left-dominant temporal lobe WMH asymmetry was associated with poorer cognition in APOE4 non-carriers, but not APOE4 carriers (Fig. 3). Conclusions: Leftward asymmetry of WMH may be suggestive of WMH of a more pathological nature, as opposed to symmetrical WMH. APOE4-negative MCI and AD subjects demonstrated an association between left-dominant WMH asymmetry, and poorer cognitive outcomes.