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P1‐302: FREEZING OF SPEECH SINGLE QUESTIONNAIRE AS A SCREENING TOOL FOR DEMENTIA WITH LEWY BODIES
Author(s) -
Chiu Pai-Yi,
Tsai Ching-Fang
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.857
Subject(s) - dementia with lewy bodies , dementia , parkinsonism , audiology , lewy body , rem sleep behavior disorder , parkinson's disease , psychology , disease , clinical dementia rating , medicine , association (psychology) , psychiatry , psychotherapist
Background: Freezing phenomenon is a striking feature for Parkinson’s disease (PD). However, it has never been studied in dementia with Lewy bodies (DLB). We designed a freezing of speech single questionnaire (FOSSQ) and investigated the frequency and association of freezing of speech (FOS) phenomenon in neurodegenerative disorders including Alzheimer’s disease (AD), PD, and DLB. Methods: This is a retrospective analysis of data from a project of history-based computerized dementia diagnostic system. The original FOSSQ is writing in Chinese and the tentative translation to English is “When speaking, does he/she pause frequently, seem blank, and has trouble communicating?”. Frequencies and association factors of FOS among non-demented (ND), patients with AD, PD, and DLB were explored and compared. Results: A total of 928 individuals were studied, including 301 ND, 352 AD, 128 PD, and 127 DLB. Compared to ND (2.0%), AD (6.8%), PD (14.8%), DLB (48.8%) showed much higher frequency of FOS (all p<0.001). The FOS positive group are older (t1⁄4 4.452; p<0.001) and with higher dementia stages according to the Clinical Dementia Rating Scale (CDR, c1⁄4 115.47; p<0.001). After adjustment for age and CDR, the association factors for FOS were diagnosis of Lewy body disease (DLB or PD), attention deficit, fluctuating cognition, visual hallucinations, parkinsonism, REM sleep behavior disorder, and urinary incontinence. Conclusions: Our study showed the FOSSQ may be a practical screening tool for the discrimination of DLB from non-demented or other neurodegenerative disorders. The FOSSQ can be applied in clinical practice as well as in the artificial intelligent platform.