Premium
P1‐300: SUBTHRESHOLD DEPRESSION AND ITS ASSOCIATION WITH IMMEDIATE RECALL AND RECOGNITION IN A MULTIDOMAIN ASSOCIATIVE MEMORY TEST IN ELDERLY MEXICAN ADULTS
Author(s) -
Flores-Vazquez Juan Francisco,
Castellanos-Maya Osvaldo,
Contreras-López José Juan,
Cruz-Contreras Cecilia,
Gómez-Martínez Rodrigo,
Andrés-Benito María del Pilar,
Acosta-Castillo Gilberto Isaac,
Sosa-Ortiz Ana Luisa,
Enriquez-Geppert Stefanie
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.855
Subject(s) - dementia , recall , geriatric depression scale , psychology , association (psychology) , memory impairment , cognition , depression (economics) , episodic memory , audiology , content addressable memory , clinical psychology , psychiatry , medicine , depressive symptoms , cognitive psychology , disease , artificial intelligence , artificial neural network , computer science , psychotherapist , economics , macroeconomics
pathology. The problem is, however, that it appears that the clinical syndromic features for lvPPA are too narrow to capture Alzheimerrelated PPA. In many cohorts a non-negligible number of participants have a diffuse profile of impairment that goes beyond the criteria for lvPPA yet these patients often have underlying Alzheimer’s pathology (Villarejo-Galende et al., 2017). In this study, a clinically unbiased method was adopted to investigate the cognitive profile of patients with confirmed amyloid pathology. Methods: 26 patients fulfilling the general criteria for PPA were included and administered an extensive neuropsychological test battery as well as an F-Florbetaben Positron Emission Tomography (PET). 11 PPA patients had a positive amyloid PET (Aß+PPA). The neuropsychological profile of Aß+PPA was investigated and compared to 28 HC and 15 PPA patients with negative PET (9 SvPPA & 6 NfvPPA). Results: Confirming expectations, NfvPPA were impaired in grammar and relatively preserved in semantics whereas SvPPA showed the opposite pattern. Only one Aß+PPA patient fulfilled the criteria for LvPPA. The remaining Aß+PPA patients, in contrast, had an extensive language deficit that affected tests of semantics and grammar to a comparable extent. Moreover, repetition deficits were typically present not just for sentences but also at the single word level in Aß+PPA. Conclusions: The study confirms that the criteria for LvPPA are too narrow to allow a sensitive prediction of Alzheimer’s disease in the context of PPA. A pervasive language impairment seems to be the rule in Aß+PPA rather than an exception. Moreover, repetition of words versus sentences does not seem valuable for the differential diagnosis with NfvPPA.