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P1‐288: DEVELOPMENT OF AN INFORMANT‐REPORT SUBJECTIVE COGNITIVE DECLINE QUESTIONNAIRE
Author(s) -
Goodridge Rebecca,
Turchan Maxim,
Liu Dandan,
Hohman Timothy J.,
Jefferson Angela L.,
Gifford Katherine A.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.843
Subject(s) - item response theory , item bank , operationalization , psychology , trait , logistic regression , cognition , latent variable , clinical psychology , differential item functioning , medicine , psychometrics , psychiatry , statistics , philosophy , mathematics , epistemology , computer science , programming language
patients with the subjective cognitive decline (SCD), amnestic mild cognitive impairment (aMCI) and dementia due to Alzheimer’s disease (AD) using the cortical thickness analysis. Methods: Total 196 patients with SCD (n1⁄454), aMCI (n1⁄438) and AD (n1⁄4104) who completed the MBI-C and high-resolution 3T brain MRI were included in this study. The MBI-C was conducted by caregivers and cortical thickness was measured by the surface-based morphometric analysis with FreeSurfer. The correlation analysis was performed using the General Linear Model in order to evaluate the relationship between cortical thickness value and 6 MBI-C scores (subdomain scores of the decreased motivation, affective dysregulation, impulse dyscontrol, social appropriateness, and abnormal perception or thought content and total score of MBI-C). Results: After controlling demographics, in all patients, the MBI-C total score was associated with decreased cortical thickness in the left dorsolateral prefrontal cortex, left temporal pole and right temporal cortex. The decreased motivation domain score was associated with cortical thinning in the left dorsolateral prefrontal cortex, left inferior temporal cortex, left parietal cortex, right medial frontal cortex, right temporal cortex and bilateral precuneus. In the patients with AD, the only decreased motivation domain score was associated with cortical thinning in the left dorsolateral prefrontal cortex and right medial frontal cortex. There were no brain regions showing significant correlation between cortical thickness and MBI-C scores in the patients with SCD and aMCI. Conclusions: The MBI-C total and decreased motivation domain scores were significantly correlated with cortical thinning in several cortical regions in the neurodegenerative disorders. Our results indicate that the MBI-C might be useful for showing neurodegenerative cortical changes related with neuropsychiatric symptoms in the dementia stage of Alzheimer’s disease, rather than in the preclinical and prodromal stages.