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P1‐283: ABBREVIATED QUESTIONNAIRE OF MNESIC COMPLAINT: VALIDATION STUDY
Author(s) -
Labos Edith,
Trojanowski Sofia,
Zabala Karina,
Del Rio Miriam,
Renato Alejandro,
Seinhart Daniel Bernardo,
Mauriño Alberto
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.838
Subject(s) - context (archaeology) , psychology , dementia , retrospective memory , neurocognitive , population , cognition , memory clinic , clinical psychology , medicine , audiology , episodic memory , psychiatry , cognitive impairment , disease , explicit memory , paleontology , environmental health , biology
Background: JART (Japanese Adult Reading Test) was developed and is utilized as the Japanese version of NART. JART score is assumed to be less affected in Alzheimer’s disease (AD) compared to MMSE and ADAS. Although its capacity to estimate premorbid IQ is established, its role of cognitive reserve in AD has not been studied well. In this study we investigated characteristic features of JART using other cognitive scores and downstream imaging biomarkers. Methods: Subjects were 51 cognitively-normal (CN, 74.064.7 y.o.), of which 11 were amyloid positive, 11 mild cognitive impairment due to AD (amyloid positive) (MCI, 76.964.4 y.o.), 6 patients with dementia due to Alzheimer’s disease (ADD, 75.368.2 y.o.). The clinical categories were based on the criteria of ADNI and NIA-AA. The relationships between cognitive measures (JART, WMS-R logical memory 2 (LM2), and ADAS) and images (FDG-PET, THK 5351-PET, and gray matter derived from MR image) were analyzed with SPM regression analysis. SPSS software was used for logistic regression analyses evaluating effect of JART score or years of school education (YSE) along with age, PET score (derived from FDG-PET by PALZ software), and z-score (derived from MRI by VSRAD software) on the clinical categories (CN (0) or MCI+ADD (1) as dichotomous dependent variable) and for correlation analyses among the parameters. Results: In all subjects, lower LM2 and higher ADAS scores correlated with lower FDG uptake levels in the precuneus, posterior cingulate cortex, and inferior temporal lobe, with smaller medial temporal gray matter volume, and with higher THK5351 uptake in the inferior frontal, inferior temporal, and occipital lobe (p<0.01). In contrast, no significant association was found between JART and these images. In CN JART showed a positive correlation with YSE (p<0.001, r>0.608). In the logistic regression analyses, significant independent variables (p<0.05) were JART score (coefficient B<0), PET score (B>0), and z-score (B>0), whereas YSE and age did not reach significance level. Conclusions: Our study suggests that JART score is less influenced by the progression of AD and has a protective effect against the conversion from CN to cognitively impaired status.