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P1‐276: NEUROPSYCHIATRIC SYMPTOMS IN PATIENTS WITH MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASE FROM THE MEMORY CLINIC IN CHONGQING, CHINA
Author(s) -
Zhang Wenbo,
Yu Weihua,
Wang Xia,
Lü Yang
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.831
Subject(s) - medicine , apathy , memory clinic , irritability , dementia , odds ratio , clinical dementia rating , depression (economics) , confidence interval , cohort , anxiety , psychiatry , disease , pediatrics , economics , macroeconomics
(VBM) in AD. Methods: Longitudinal plasma NfL was measured using an in-house Single molecule array method in 1159 ADNI participants (382 CU, 424 MCI and 352 AD) with matched MRI. MRI were segmented into probabilistic grey (GM) and white (WM) maps, non-linearly registered to the ADNI template using Dartel and smoothed with an 8mm FWHM gaussian kernel. Voxel based linear mixed-effect models were used to examine the association between plasma NfL and VBM, correcting for age, gender, diagnosis and time difference between the measurements. Results: NfL was highly and inversely correlated with WM and GM volumes. Atrophic GM regions associated with NFL, including the inferior temporal, posterior cingulate and frontal cortices. Additionally, NfL associated with widespreadWM loss (Figure 1A). In the group analysis, AD showed larger areas of reduced tissue density, as compared to CU (Figure 1B). Conclusions: The increase in NfL is associated with widespread WM atrophy and GM loss in ADrelated regions, providing further evidence supporting the use of NfL as marker of progressive neuronal damage.