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P1‐258: PROGNOSIS OF CONVERSION TO MILD COGNITIVE IMPAIRMENT AND TIME TO STABLE CHANGES VIA MEMORY‐RELATED ELECTROPHYSIOLOGICAL BRAIN SIGNATURES
Author(s) -
Jiang Yang,
Li Juan,
Jicha Gregory A.,
Smith Charles D.,
Munro Nancy,
Zhao Xiaopeng,
Schmitt Frederick A.,
Kryscio Richard J.,
Abner Erin L.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.813
Subject(s) - audiology , psychology , neuropsychology , neuropathology , electroencephalography , cognition , dementia , memory impairment , electrophysiology , episodic memory , neuroscience , medicine , disease
and compare lumbar (L-) and ventricular (V-) CSF. Methods: CSF was collected prior to CSF shunt by lumbar puncture. In addition, simultaneous lumbar (L-CSF) and shunt valve puncture (V-CSF) at 0 (1-73 months after CSF shunt placement), 3, 6 and 18 months in 39 patients shunted due to iNPH (26 with confirmed amyloid-b (Ab) plaques and 13 patients without Ab pathology in right frontal cortical brain biopsy) at the KUH in Finland. CSF samples were analyzed with commercial ELISAs. Results: Absolute levels of all four biomarkers correlated highly between V-CSF and L-CSF (T-tau: R 1⁄4 0.83, P-T181-tau: R 1⁄4 0.92, NFL: R 1⁄4 0.94, Ng: R 1⁄4 0.9; all P < 0.0001) but were systematically lower in V-CSF (T-tau: 22%, P-tau: 20%, NFL: 32%, Ng: 21%). No significant difference was seen in the levels of T-tau, PT181-tau and Ng over 18 months either in L-CSF or V-CSF. However, the NFL levels showed an overall decrease of 6% per month. Conclusions: The levels of measured biomarkers were 20-30% lower in intraventricular CSF compared with lumbar. Longitudinal follow up of 18 months shows that after initial upregulation postsurgery, T-tau, P-tau and Ng are stable in iNPH patients irrespective of the brain biopsy Ab pathology, while NFL normalized towards its pre-shunt levels.