Premium
P1‐234: THE A/T/N BIOMARKERS SCHEME ASSESSED IN EARLY‐ONSET ALZHEIMER'S DISEASE SPECTRUM
Author(s) -
Migliaccio Raffaella,
Houot Marion,
Ben Abdallah Ines,
Chamayou Celine,
La Corte Valentina,
Ferrieux Sophie,
Epelbaum Stéphane,
Dubois Bruno,
Michon Agnès
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.789
Subject(s) - pathological , disease , medicine , early onset alzheimer's disease , biomarker , psychology , oncology , alzheimer's disease , biology , biochemistry
show that mean CLIC1 mRNA expression in blood is statistically higher in AD patients compared with patients who exhibit normal cognitive function or mild dementia. CLIC1 has previously been linked to AD and induces neurotoxin production in the presence of beta-amyloid (Abeta) protein. These results implicate CLIC1 for follow-up gene expression studies. Furthermore, we achieved high CDR classification accuracy using solely mRNA expression microarray data taken from blood, which could aid in the development of a non-intrusive diagnostic tool for assessing AD status.