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P1‐170: OPTOGENETIC ACTIVATION OF BLP TO VENTRAL CA1 INPUTS IMPROVES ANXIETY AND MEMORY DEFICIT IN AD MICE
Author(s) -
Pi Guilin
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.725
Subject(s) - optogenetics , anxiety , elevated plus maze , neuroscience , cognition , medicine , psychology , psychiatry
cortex formation (Figure 1, 2). Conclusions: Our findings demonstrate that Immunocal induces Reelin expression in vivo within the hippocampal-entorhinal cortex formation of 12-month-old mice. This rescue of Reelin expression reduced cognitive deficits in the mice and ameliorated the pathological amyloid plaque load. To our knowledge, these data provide the first evidence of a therapeutic agent that is capable of correcting Reelin deficits observed in the hAPPSweInd J20 mouse model of AD.