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P1‐169: ALLOSTERIC REGULATION OF α7 NACHRS BY LOW AND HIGH Aβ(1‐42) CONCENTRATIONS
Author(s) -
Anderson Jonathan Blake,
Panchal Jayharsh L.,
DeBoeuf Kristi,
Islam Mohammad F.,
Mcfatridge Ian,
Farley Joseph
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.724
Subject(s) - xenopus , allosteric regulation , chemistry , voltage clamp , allosteric modulator , biophysics , protein subunit , facilitation , electrophysiology , microbiology and biotechnology , patch clamp , biology , membrane potential , receptor , biochemistry , neuroscience , gene
cortex formation (Figure 1, 2). Conclusions: Our findings demonstrate that Immunocal induces Reelin expression in vivo within the hippocampal-entorhinal cortex formation of 12-month-old mice. This rescue of Reelin expression reduced cognitive deficits in the mice and ameliorated the pathological amyloid plaque load. To our knowledge, these data provide the first evidence of a therapeutic agent that is capable of correcting Reelin deficits observed in the hAPPSweInd J20 mouse model of AD.