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P1‐168: IDENTIFICATION OF AMINO‐TRUNCATED AMYLOID BETA PEPTIDE 3–42 (AβN 3‐42 ) IN AGE‐RELATED CATARACT IN HUMAN PATIENTS
Author(s) -
Martínez-Zúñiga Nayeli,
López de Eguileta Alicia,
Quiroz-Mercado Hugo,
Gevorkian Goar,
Torres-Romero Abigail,
Gonzalez-Salinas Roberto,
Corredor-Ortega Claudia,
Luna-Muñoz José,
Hernández-Zimbrón Luis Fernando
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.723
Subject(s) - senile plaques , senile cataract , medicine , lateral geniculate nucleus , ophthalmology , amyloid (mycology) , pathology , phacoemulsification , alzheimer's disease , disease , biology , visual cortex , visual acuity , neuroscience
cortex formation (Figure 1, 2). Conclusions: Our findings demonstrate that Immunocal induces Reelin expression in vivo within the hippocampal-entorhinal cortex formation of 12-month-old mice. This rescue of Reelin expression reduced cognitive deficits in the mice and ameliorated the pathological amyloid plaque load. To our knowledge, these data provide the first evidence of a therapeutic agent that is capable of correcting Reelin deficits observed in the hAPPSweInd J20 mouse model of AD.