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P1‐117: ASSOCIATION OF CENTRAL ARTERIAL STIFFNESS WITH HIPPOCAMPAL BLOOD FLOW, N‐ACETYL‐ASPARTATE AND ANXIETY IN HYPERTENSIVE DAHL SALT SENSITIVE RATS
Author(s) -
Ajamu Samuel,
Fenner Rachel C.,
Lakatta Edward G.,
Bouhrara Mustapha M.,
Spencer Richard G.,
Fishbein Kenneth W.,
Fedorova Olga V.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.672
Subject(s) - hippocampal formation , arterial stiffness , cerebral blood flow , medicine , blood pressure , pulse wave velocity , hippocampus , endocrinology , cardiology , blood flow
neuroinflammation, neurofibrillary tangles, and neuronal death. In this study, we compared male and female TgF344-AD (Tg) rats to wild-type rats at 5-6, 13-15, and 20-22 months of age on a battery of cognitive tests. Behavioral paradigms included novel object recognition (NOR; a measurement of episodic memory) and Barnes maze (a hippocampus-dependent spatial reference learning and memory task). The goal of the study being to cognitively evaluate two sexes of AD rats before, during, and after development of AD pathological changes. Results: In the NOR task, 13-15 and 20-22-month-old female Tg rats lack the ability to discriminate between novel and familiar objects, demonstrating impaired episodic memory. In Barnes maze, animals undergo two days of reversal following learning and testing phases. In reversal, both aged groups (13-15 and 20-22-months-old) of female Tg rats displayed impaired spatial memory with significantly more errors (P<0.001) vs. male Tg rats. Interestingly, when comparing latency to reach the escape goal during the reversal phase, 13-15month-old male Tg rats took significantly longer (P<0.05) to complete the task. Yet, at 20-22 months, female Tg rats took longer (p<0.05) than male counterparts to reach the reversal goal. No significant sex differences were observed in the learning phase of the Barnes maze task when considering error or latency measures, suggesting that females do not have impaired spatial learning. Conclusions: Overall results of this study suggest a complex relationship between sex and memory deficits in the TgF344AD rat model.