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P1‐100: CINNAMALDEHYDE EXERTS A BIPHASIC EFFECT ON PASSIVE AVOIDANCE MEMORY IN ADULT MALE MICE
Author(s) -
Moosavi Maryam,
SoukhakLari Roksana,
Borhani-Haghighi Afshin,
Farsadrooh Ava,
Moezi Leila,
Pirsalami Fatema,
Safari Anahid
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.655
Subject(s) - cinnamaldehyde , mapk/erk pathway , hippocampus , protein kinase b , pharmacology , hippocampal formation , amnesia , medicine , psychology , chemistry , neuroscience , phosphorylation , biochemistry , psychiatry , catalysis
expression of leucine carboxyl methyltransferase 1 (LCMT-1), and elevated level of protein tyrosine phosphatase 1B (PTP1B) and protein phosphatase 2A phosphatase activator (PTPA). Conclusions:CIG showed beneficial effects in both cognitive and behavioral function of rTg4510 mice, prevented brain atrophy and neuronal loss. By downregulating tau hyperphosphorylation and pathology, CIG protected cytoskeleton and synapse of neurons. Corresponding mechanisms were involved in the increase of PP2A activity and PTPA expression after CIG treatment. In conclusion, CIG might be a potential medication for AD via PP2A regulation.