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P1‐093: NOVEL PARTIAL MITOCHONDRIAL COMPLEX I INHIBITORS AS DISEASE‐MODIFYING THERAPEUTICS FOR TREATMENT OF ALZHEIMER'S DISEASE
Author(s) -
Trushin Sergey,
Stojakovic Andrea,
Chang Su-Youne,
Trushina Eugenia
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4957
Subject(s) - mitochondrial biogenesis , pharmacology , alzheimer's disease , chemistry , phenotypic screening , mitochondrion , medicine , biochemistry , disease , phenotype , gene
compounds Y12d, Y12e, Y12f and Y12j possessed preferably good docking score showing the interaction with both PAS and CAS of AChE. All the compounds of Y13 except Y13a and Y13b exhibit good docking score (-8.3 to -10.6) and shows interaction with HIS440 through p-p interaction and with ASP72, PHE331 and TYR334 through H-bonding. Conclusions: The study reveals the importance of chain length combining the two moieties i.e., chain length of 2-3 atoms is most appropriate for good affinity towards AChE.