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Differential expression of microRNAs in Alzheimer's disease brain, blood, and cerebrospinal fluid
Author(s) -
Takousis Petros,
Sadlon Angélique,
Schulz Jessica,
Wohlers Inken,
Dobricic Valerija,
Middleton Lefkos,
Lill Christina M.,
Perneczky Robert,
Bertram Lars
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4952
Subject(s) - microrna , cerebrospinal fluid , disease , pathology , differential diagnosis , alzheimer's disease , pathogenesis , medicine , bioinformatics , biology , gene , genetics
Several microRNAs (miRNAs) have been implicated in Alzheimer's disease pathogenesis, but the evidence from individual case‐control studies remains inconclusive. Methods A systematic literature review was performed, followed by standardized multistage data extraction, quality control, and meta‐analyses on eligible data for brain, blood, and cerebrospinal fluid specimens. Results were compared with miRNAs reported in the abstracts of eligible studies or recent qualitative reviews to assess novelty. Results Data from 147 independent data sets across 107 publications were quantitatively assessed in 461 meta‐analyses. Twenty‐five, five, and 32 miRNAs showed studywide significant differential expression (α < 1·08 × 10 −4 ) in brain, cerebrospinal fluid, and blood‐derived specimens, respectively, with 5 miRNAs showing differential expression in both brain and blood. Of these 57 miRNAs, 13 had not been reported in the abstracts of previous original or review articles. Discussion Our systematic assessment of differential miRNA expression is the first of its kind in Alzheimer's disease and highlights several miRNAs of potential relevance.