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IC‐P‐087: ASSOCIATION BETWEEN COGNITION AND CEREBRAL WHITE MATTER FREE WATER IN ADULTS FROM THE FRAMINGHAM HEART STUDY: A DIFFUSION TENSOR IMAGING VOXEL‐BASED STUDY
Author(s) -
Maillard Pauline,
Himali Jayandra J.,
Beiser Alexa S.,
Fletcher Evan,
Peets Bryanne,
Satizabal Claudia L.,
Seshadri Sudha,
DeCarli Charles
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4930
Subject(s) - fractional anisotropy , diffusion mri , white matter , corpus callosum , population , psychology , neuropsychology , boston naming test , voxel , audiology , verbal memory , cognition , medicine , neuroscience , magnetic resonance imaging , environmental health , radiology
dysnomic cluster (n 1⁄4 31; mean age 84; 45% women) had atrophy in the entorhinal cortex, temporal pole, inferior/middle/superior temporal gyri, supramarginal gyrus, inferior parietal lobe, precuneus, and frontal pole. The dysexecutive cluster (n 1⁄4 50; mean age 83; 36% women) had atrophy in entorhinal cortex, parahippcampal/ fusiform/lingual gyri, middle/superior temporal gyri, supramarginal gyrus, inferior parietal lobe, and medial/lateral frontal regions. The SCI and Dysnomic clusters had relatively more left-sided atrophy whereas the Amnestic and Dysexecutive clusters had bilateral atrophy. (See Figure). Conclusions: We found distinct atrophy patterns in each of the neuropsychologically derived clusters of individuals with incident MCI that corresponded to their patterns of cognitive impairment. The identification of MCI subtypes based on cognitive and structural features may allow for more efficient trial and study designs. Given individuals in the SCI cluster have less structural changes and cognitive decline and may represent the earliest group, this could be a unique group to target with early interventions.