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IC‐P‐086: CORTICAL ATROPHY PATTERNS OF EMPIRICALLY DERIVED INCIDENT MCI SUBTYPES IN THE MAYO CLINIC STUDY OF AGING
Author(s) -
Machulda Mary M.,
Lundt Emily S.,
Albertson Sabrina M.,
Spychalla Anthony J.,
Mielke Michelle M.,
Jack Clifford R.,
Kremers Walter K.,
Vemuri Prashanthi,
Knopman David S.,
Bondi Mark W.,
Petersen Ronald C.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4929
Subject(s) - precuneus , temporal lobe , entorhinal cortex , psychology , supramarginal gyrus , atrophy , fusiform gyrus , parahippocampal gyrus , temporal cortex , middle frontal gyrus , orbitofrontal cortex , audiology , neuroscience , medicine , hippocampus , cognition , prefrontal cortex , epilepsy , functional magnetic resonance imaging
Toolbox tests, adjusted for age, gender, and global CBF. A twosided Wilcoxon rank-sum test determined if the median LSAD*MCAperfCBF was significantly different for patient vascular risk factors and Global CDR. Results: Figure 1 shows correlation for right MCAperf CBF (p1⁄40.039) and LSAD. LSAD*MCAperfCBF was significantly positively correlated with MoCA z-score and various executive function scores for NIH Toolbox tests (Figure 2). Figure 3 shows boxplots for Global CDR and history of hyperlipidemia, with higher median LSAD*MCAperfCBF for normal subjects. Figure 4 shows an example of 2 subjects’ LSAs and their clinical data. With poorer vessel quality, MCAperfCBF, plus vascular risk factors, cognitive function appears to decline. Conclusions: High resolution T1wVFA-TSE can be used with pCASL to characterize the status of LSAs and subcortical perfusion in patients with vascular risk factors, and they may serve as a potential imaging marker to identify early small vessel changes related to vascular cognitive impairment and dementia.