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IC‐P‐082: ASSOCIATION OF PERCEIVED MEMORY DECLINE WITH MULTIMODAL NEUROIMAGING AT DIFFERENT STAGES OF ALZHEIMER'S DISEASE
Author(s) -
Kuhn Elizabeth,
De la Sayette Vincent,
Perrotin Audrey,
Tomadesso Clémence,
André Claire,
Sherif Siya,
Bejanin Alexandre,
Moulinet Inès,
Touron Edelweiss,
Landeau Brigitte,
Mézenge Florence,
Marchant Natalie L.,
Delarue Marion,
Delcroix Nicolas,
Abbas Ahmed,
Manrique Alain,
Eustache Francis,
Vivien Denis,
Chetelat Gaelle
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4925
Subject(s) - neuroimaging , cognitive decline , alzheimer's disease neuroimaging initiative , alzheimer's disease , psychology , disease , anosognosia , cognition , memory impairment , medicine , dementia , psychiatry
maps were generated using MPnRAGE and subsequently skullstripped, realigned and normalized to a 1mm T1-weighted MNI template, and segmented by tissue type using gray and white matter MNI templates within SPM12. Average T1 (in ms) was extracted from the resulting gray and white matter T1 maps. Multiple regression models were estimated using R to determine relationships with CSF biomarkers (log transformed for normality). Primary analyses focused on markers of neurodegeneration including total tau, neurogranin, and neurofilament light protein (NFL). Secondary analyses examined relationships with AD biomarkers ptau and Aß42/ Aß40 ratio on quantitative T1, while controlling for age, sex, APOE status, and time between MRI and CSF sample collection. Results: Higher total tau was associated with higher T1 in gray matter (b1⁄4 62.735 [4.22, 121.25], F(1, 39)1⁄4 4.703, p1⁄4 0.036). There were no significant relationships between phosphorylated tau, NFL, and Aß42/40 ratio and quantitative T1 in gray and white matter, although higher neurogranin was unexpectedly associated with higher T1 in white matter (b 1⁄4 94.346 [9.503, 179.188], F(1, 37) 1⁄4 5.077, p1⁄4 0.03). Conclusions: We found that CSF tau—a marker of neurodegeneration—was associated with higher quantitative T1, potentially suggesting myelin loss and/or increased water content due to neurodegeneration. The relationship was measurable even among cognitively unimpaired adults, and when controlling for age. Additional studies with larger samples will determine whether quantitative T1 may be useful for mapping neurodegeneration in the context of Alzheimer’s, and the NIA-AA research framework.