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IC‐P‐080: SLEEP‐WAKE CYCLE AND 2‐YEAR CHANGES OF ALZHEIMER'S DISEASE NEUROIMAGING BIOMARKERS AND COGNITION
Author(s) -
Jeon So Yeon,
Byun Min Soo,
Yi Dahyun,
Lee Jun Ho,
Choe Young Min,
Sung Kiyoung,
Han Myeong-Il,
Jung Jung Gi,
Lee Han Na,
Shin Seong A.,
Kim Yu Kyeong,
Lee Yu Jin,
Lee Dong Young
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4923
Subject(s) - dementia , actigraphy , neuroimaging , medicine , confounding , alzheimer's disease , cognitive decline , circadian rhythm , cohort , alzheimer's disease neuroimaging initiative , prospective cohort study , psychology , disease , psychiatry
correlated with global cognition (i.e. Mini Mental Score Examination MMSE, r1⁄4-0.688, p<0.001), outperforming all other PIB6/ FTP6/ND6 voxel classifications (Fig.2C). Conclusions: On average, amyloid-PET changes were more extensive than tau and neurodegeneration imaging changes, matching the expected temporal relationships between biomarkers, but notably with some age-related heterogeneity. Neurodegeneration frequently co-localized with both amyloid/tau pathology accumulation, suggesting a possible shared vulnerability or synergistic toxic effects. Global cognition correlated with the proportion of PIB+/FTP+/ND+ cortical voxels suggesting that cognitive decline may be explained by the confluence of molecular pathology and neurodegeneration.