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IC‐P‐058: COVARYING SPATIAL PATTERNS OF TAU DEPOSITION AND GRAY MATTER ATROPHY UNEARTHED BY THE INFORMED MULTIMODAL PARTIAL LEAST SQUARES (MMPLS) IN AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE: FINDINGS FROM THE COLBOS PROJECT
Author(s) -
Protas Hillary,
Pardilla-Delgado Enmanuelle,
Lopera Francisco,
Johnson Keith A.,
Sperling Reisa A.,
Artola Arabiye,
Baena Ana,
Bocanegra Yamile,
Gatchel Jennifer R.,
Guzman-Velez Edmarie,
Fuller Joshua,
Goradia Dhruman D.,
Thiyyagura Pradeep,
VanGilder Paul S.,
Luo Ji,
Ghisays Valentina,
Lee Wendy,
Malek-Ahmadi Michael,
Chen Yinghua,
Devadas Vivek,
Chen Kewei,
Reiman Eric M.,
Su Yi,
Quiroz Yakeel T.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4901
Subject(s) - atrophy , psen1 , voxel , white matter , neuroscience , population , presenilin , pathology , neurodegeneration , alzheimer's disease , psychology , magnetic resonance imaging , medicine , disease , radiology , environmental health
(corrected p-value<0.05; Table 2): Fc gamma R-mediated phagocytosis, osteoclast differentiation, and tuberculosis. In ADNI, 25 genes belonged to the Fc gamma R-mediated phagocytosis pathway (Table 2), of which 2 genes (ASAP1and PRKCD) were significantly dysregulated in AD and replicated in AddNeuroMed (corrected pvalue<0.05). Further analysis showed that the brown module in ADNI was significantly associated with neuroimaging biomarkers measured fromMRI and PET scans (Table 3 and Figure 2). Conclusions: We identified and replicated that Fc gamma R-mediated phagocytosis pathway was dysregulated in AD, which supports previous findings that the peripheral immune system might play a role in AD (Le PageA, et al. 2017). Fc gammaR-mediated phagocytosis pathway is one of the clearance mechanisms of amyloid-b in the brain (Okun E, et al. 2010).