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O5‐01‐06: EARLY TAU DETECTION AND IMPLICATIONS FOR DISEASE PROGRESSION
Author(s) -
Kotari Vikas,
Navitsky Michael,
Southekal Sudeepti,
Kennedy Ian,
Harris Thomas,
Lu Ming,
Mintun Mark A.,
Fleisher Adam S.,
Pontecorvo Michael J.,
Devous Michael D.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4839
Subject(s) - parahippocampal gyrus , entorhinal cortex , temporal lobe , fusiform gyrus , inferior temporal gyrus , neurodegeneration , tau pathology , psychology , medicine , cognition , neuroscience , audiology , nuclear medicine , alzheimer's disease , hippocampus , disease , epilepsy
temporoparietal cortex F-MK6240 binding (Fig 1, top). Six of 24 (33%) of Ab+MCI and 6 of 24 (25%) Ab+HC had high F-MK6240 mesial temporal binding (Fig 1, bottom). With the exception of one Ab-HC, temporoparietal F-MK6240 retention in Ab-HC and OD was low. Compared to Ab-HC, significantly higher SUVR was observed in Ab+HC in mesial temporal (0.9560.17vs.1.2760.42, p1⁄40.0014), but not in temporoparietal cortex (1.0160.14vs.1.1760.39, p1⁄40.32). Significantly higher SUVRwas observed in Ab+AD compared to Ab-HC inmesial temporal (2.0960.75 vs. 0.9460.18, p<0.0001, Cohen’s d1⁄42.1), and temporoparietal cortex 2.9361.75 vs. 1.0160.13, p<0.0001, Cohen’s d1⁄41.5). Conclusions: F-MK6240 yields high contrast images that allows robust discrimination between Ab-HC and Ab+AD. Furthermore, the low non-specific binding suggests F-MK6240 is an suitable tracer to detect small changes in tau burden in the brain.