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F5‐02‐02: HIGHER LITERACY ASSOCIATES WITH BETTER BRAIN STRUCTURE AND COGNITION IN MIDDLE‐AGED INDIVIDUALS
Author(s) -
Paula França Resende Elisa,
Kaup Allison R.,
Launer Lenore J.,
Sidney Stephen,
Schreiner Pamela,
Xia Feng,
Erus Guray,
Bryan Nick,
Yaffe Kristine
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4828
Subject(s) - fractional anisotropy , cognition , white matter , psychology , literacy , diffusion mri , logistic regression , effects of sleep deprivation on cognitive performance , medicine , clinical psychology , gerontology , neuroscience , magnetic resonance imaging , pedagogy , radiology
with ApoE4; increasing from 0.15 among thosewith no e4 alleles to 0.29 with one and 0.35 for those with two e4 alleles (p1⁄40.01). In a one-way ANOVA analysis, we did not find a relationship between Admixture proportions and Cognitive Score. Extending the model to include APOE genotype by African ancestry and adjusting for covariates, the interaction suggested that having any E4 allele had a weaker effect on the overall cognitive scores, memory, language, and executive functioning in those with higher African Admixture; showing a significant effect of ApoE4 on cognitive decline among those with lower African Admixture (p<0.001). Conclusions: E4 frequency was over-represented in those with higher African Ancestry. The effect of APOE e4 on cognitive decline was substantially attenuated among those with a higher proportion African ancestry, suggesting that genes linked to admixture may reduce the risk for dementia by modifying the effect of APOE genotype.