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O4‐11‐02: DEFINING COGNITION IN PRE‐DEMENTIA CLINICAL TRIALS: BASELINE NEUROPSYCHOLOGICAL DATA FROM THE TOMMORROW STUDY
Author(s) -
Welsh-Bohmer Kathleen A.,
Atkins Alexandra S.,
Plassman Brenda L.,
Khan Anzalee,
Chiang Carl,
Culp Meredith,
O'Neil Janet,
Walter Ryan,
Haneline Stephen,
Arbuckle Julian,
Brewster Shyama,
Maruyama Yuka,
Swanson Tom,
Hayden Kathleen M.,
Romero Heather,
Keefe Richard SE.,
Saunders Ann M.,
Burns Daniel K.,
Alexander Robert
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4801
Subject(s) - neuropsychology , verbal fluency test , dementia , memory span , psychology , cognition , neuropsychological test , neuropsychological assessment , clinical trial , boston naming test , clinical psychology , audiology , medicine , gerontology , disease , psychiatry , working memory
guidance to support a healthy diet, cognitive training, increased social engagement, and better management of cardiovascular risk factors effectively improved cognition in cognitively normal older adults who were at increased risk of decline. While these results are encouraging, they were limited to a single country and thus, there is a need to test and adapt the intervention in other geographical, economic and cultural settings.Methods: TheWorldwide FINGERS (WW-FINGERS) initiative was established to support and convene global multi-domain dementia prevention trials, share experiences and data and harmonize methods. The WW-FINGERS Consortium will test multi-domain interventions, modeled after FINGER in diverse populations around the world, and comprises studies at different stages of implementation and comparison to FINGER. The Alzheimer’s Association provides the research community with the Global Alzheimer’s Association Interactive Network (GAAIN) to network and link, in a federated manner, diverse data sets from around the world. Results: WW-FINGER studies are underway or set to begin soon in several countries. As WW-FINGERS expands and studies initiate, it will be important for all initiatives to align so that study data are interpreted, implemented, and validated in a consistent manner and that privacy and confidentiality are maintained. WW-FINGERS will enable the testing many hypotheses in addition to whether a multi-domain intervention can slow cognitive decline. Conclusions: By collectively convening these research teams under the WW-FINGERS leadership of Dr. Miia Kivipelto and Dr. Maria Carrillo, WW-FINGERS will facilitate data sharing and joint analysis across studies, establish opportunities for joint initiatives across country borders, and strengthen the potential evidence base for lifestyle multidomain interventions.