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O4‐07‐04: SUBJECTIVE COGNITIVE DECLINE HIGHER AMONG SEXUAL AND GENDER MINORITIES: POPULATION‐BASED FINDINGS FROM NINE STATES IN THE U.S.
Author(s) -
Flatt Jason,
Cicero Ethan,
Lambrou Nickolas H.,
Wharton Whitney,
Anderson Joel G.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4779
Subject(s) - behavioral risk factor surveillance system , demography , transgender , gerontology , logistic regression , medicine , population , sexual orientation , depression (economics) , lesbian , ethnically diverse , cognitive decline , health and retirement study , random digit dialing , psychology , dementia , disease , environmental health , social psychology , pathology , sociology , psychoanalysis , economics , macroeconomics
whether trends in aMCI rates have differed for white and black older adults. Methods: Age specific incidence of aMCI was examined by birth year for 1,233 individuals age 70 who were enrolled in EAS population based cohort between November 1, 1993 and February 22, 2016, did not have cognitive impairment at the time of enrollment and who had at least one annual follow-up clinic visit. aMCI was defined using the updated Petersen criteria as presence of objective memory impairment, subjective memory impairment, and absence of functional decline or clinical dementia. Poisson regression was used to model aMCI incidence as a function of age, sex, race, education and birth year. Profile likelihood was used to identify the timing of noticeable increases or drops in incidence rates, with a change point allowed to fall any time between 1915 and 1935. Additional models were adjusted for trends in self-reported history of diabetes, myocardial infarction and stroke. Results: Analyses included 5,320.9 person years of follow-up. Poisson regression analyses did not yield any significant change point in aMCI incidence rates in the overall cohort (p-value for Likelihood ratio test controlling for age, sex, race/ethnicity and education 1⁄4 0.76). This result was similar for Blacks and Whites, and among men or women born between 1915 and 1935. Although stroke history was an independent predictor of incident aMCI, inclusion of stroke, MI and diabetes in the models did not change the results Conclusions: Despite a previously reported trend for decreased dementia incidence in the EAS cohort (Derby et al. JAMANeurology 2017), a change in aMCI rates over the same period was not identified. These apparently conflicting results may indicate a delay or decrease in the rates of transition from aMCI to dementia, although further studies are needed to determine trends in aMCI incidence other populations.