Premium
O4‐04‐06: AMYLOID PET IS MORE THAN JUST POSITIVE OR NEGATIVE: AMYLOID LEVEL IMPACTS RISK OF CLINICAL PROGRESSION IN NORMAL INDIVIDUALS
Author(s) -
Kall Laura M.,
Burnham Samantha C.,
Dore Vincent,
Mulligan Rachel S.,
Bozinovski Svetlana,
Bourgeat Pierrick,
Tyrrell Regan,
Young Kenneth,
Fripp Jurgen,
Masters Colin L.,
Villemagne Victor L.,
Rowe Christopher
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4763
Subject(s) - dementia , medicine , proportional hazards model , cognition , amyloid (mycology) , cognitive decline , oncology , disease , gerontology , pathology , psychiatry
each PET ligand: one in anterior temporal regions, and another in posterior temporo-parietal regions (Figure 2). The LGCM using MRI (c2(4)1⁄42.82, p1⁄40.59, RMSEA1⁄40.00, CFI1⁄41.00) showed a positive association between grey-matter volumes and longitudinal ACE-R scores (Std all1⁄40.56, p<0.001). LGCM with [11C]PK11195 (c2(6)1⁄41.50, p1⁄40.96, RMSEA1⁄40.00, CFI1⁄41.00) indicated a positive association with 2-year cognitive decline in both anterior (Std all1⁄4-0.42, p<0.001) and posterior (Std all1⁄4-0.35, p1⁄40.016) components. Furthermore, in LGCM with [18F]AV-1451 (c2(6)1⁄4 10.63, p1⁄40.10, RMSEA1⁄40.12, CFI1⁄40.98), longitudinal cognitive performance correlated negatively with values in the posterior (Std all1⁄4-0.61, p1⁄40.01) and anterior (Std all1⁄4-0.43, p<0.001) components. Conclusions: In addition to atrophy (MRI), neuroinflammation ([11C]PK-11195) and tau ([18F]AV-1451) pathology in temporo-parietal regions predict cognitive decline over two years. This suggests a role for PET to predict cognitive decline in AD, and to investigate the mechanisms of cognitive decline as priorities for disease-modifying therapy.