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O4‐03‐02: DIFFERENTIATING FRONTOTEMPORAL DEMENTIA FROM ALZHEIMER'S DISEASE ON MEASURES OF EMPATHY
Author(s) -
Mendez Mario F.,
Carr Andrew R.,
Jimenez Elvira E.,
Riedel Brandalyn C.,
Thompson Paul M.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4753
Subject(s) - empathy , frontotemporal dementia , psychology , socioemotional selectivity theory , dementia , audiology , disease , clinical psychology , neuroscience , medicine , psychiatry
(49.5%) female, 1140 (91.6%) Caucasian, mean age 56 (range 1889) years, and mean education 16 (range 11-22) years. The most common diagnoses in the sporadic cohort are bvFTD (30%) and PSP (21%), followed by CBS (13%), svPPA (12%), nfvPPA (10%), and FTD-ALS (4%). Of 586 familial participants, 25% have a MAPT mutation in the kindred, 20% have a GRN mutation in the kindred, 34% have the C9orf72 expansion in the kindred, and 4 individuals have a double familial mutation in C9orf72 and GRN. 16% of familial participants lacked known mutations, and a small number had other FTD-associated mutations. Annual follow-up evaluations for participants in the LEFFTDS study have been completed in 278 (71%) for Visit 2, 162 (41%) for Visit 3, and 35 (9%) for Visit 4. Blood samples are currently available from 1023 individuals and MRIs from 612 participants. Conclusions: These integrated consortia are actively evaluating participants across North America to characterize FTLD and prepare sites and investigators for FTLD clinical trials. Clinical, genetic, and imaging data and biospecimens are available to investigators worldwide.