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F4‐04‐02: AGE‐RELATED CHANGES IN BASELINE COGNITIVE MEASURES IN UNIMPAIRED PSEN1 E280A MUTATION CARRIERS AND NON‐CARRIERS IN THE API AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE COLOMBIA TRIAL
Author(s) -
Acosta-Baetalia,
Rios-Romenets Silvia,
Muñoz Claudia,
Bocanegra Yamile,
Henao Eliana,
Giraldo Margarita,
Tobon Carlos,
Sink Kaycee,
Hu Nan,
Guthrie Heather,
Smith Jillian,
Cho William,
Langbaum Jessica B.,
Thomas Ronald G.,
Chen Kewei,
Su Yi,
Goradia Dhruman D.,
Thiyyagura Pradeep,
VanGilder Paul S.,
Luo Ji,
Ghisays Valentina,
Lee Wendy,
Malek-Ahmadi Michael,
Protas Hillary,
Chen Yinghua,
Ho Carole,
Suliman Shehnaaz,
Paul Robert,
Reiman Eric M.,
Tariot Pierre N.,
Lopera Francisco
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4726
Subject(s) - dementia , audiology , psen1 , cognition , psychology , neuropsychological test , medicine , neuropsychology , alzheimer's disease , presenilin , disease , psychiatry
Safety and tolerability are assessed. We developed a baseline datasharing plan to protect participant identity and trial integrity. Baseline data from multiple sources were shared (July 2018) with firewalled sponsor teams who determined what data could be analyzed and presented. The data presented are from 242 of the 252 enrolled. Statistical tests were not adjusted for multiplicity. Results: Baseline clinical and cognitive data will be presented according to mutation carriage status, including age, sex, years of education, APOE4 carriage, subjective cognitive concern, and scores for the API ADAD Composite Cognitive Test, CDR, FAST, NPI, MMSE, CERADword list recall, RBANS, and FCSRT. Compared to mutation non-carriers in the trial, mutation carriers were younger (mean 37 vs 42 years), had similar educational attainment (mean 8.8 vs 8.5 years), showed generally lower cognitive performance, with greater variance, especially on measures of memory (e.g., mean RBANS delayed memory 77.4 vs 87.3, respectively); no difference in subjective concerns regarding cognition; small differences in FAST and CDR, with greater variance; and no differences in NPI scores. Conclusions: The API ADAD Colombia Trial baseline data available provide insights into ageassociated changes in clinical and cognitive characteristics. Investigators can apply for analysis of baseline data at APIdata@ bannerhealth.com.