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O3‐14‐01: INCREASED ADHERENCE TO BRAIN‐HEALTHY BEHAVIORS IS ASSOCIATED WITH IMPROVED QUALITY OF LIFE IN OLDER ADULTS WITH COGNITIVE IMPAIRMENT
Author(s) -
Schwartz Hope EM.,
Gale Seth A.,
McFeeley Brittany,
Daffner Kirk R.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4702
Subject(s) - dementia , medicine , quality of life (healthcare) , cognition , randomized controlled trial , gerontology , physical therapy , clinical psychology , psychiatry , disease , nursing
novel potentially pathogenic gene, ZDHHC21, were identified for the first time. Patients from pedigrees without PSENs/APP mutations presented later age at onset, less severe cognitive impairment and more APOEε4 allele, compared with those from pedigrees with PSENs/APP mutations. ROC curve indicated that a FAD patient with an AAO under 60 years-old and without APOEε4 allele had more chance to possess a PSENs/APP mutation. Conclusions: The identification of 14 novel missense mutations suggests a genetic heterogeneity may exist in Chinese and other ethnics. Majority of pedigrees do not carry PSENs/APP mutations. In these pedigrees, APOEε4 might play an important role. Other pathogenic genes, as indicated by the finding of the ZDHHC21, were also involved in the development of FAD. However, all these assumptions need more and deeper studies in the future. O3-13-06 THE MS4A GENE CLUSTER IS A KEY MODULATOR OF SOLUBLE TREM2 AND ALZHEIMER DISEASE RISK Carlos Cruchaga, Bruno Benitez, Celeste M. Karch, Laura Piccio, Washington University School of Medicine, St. Louis, MO, USA; Washington University in Saint Louis, Saint Louis, MO, USA; Washington University School of Medicine, St. Louis, MO, USA; Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA. Contact e-mail: bbenitez@DOM.wustl.edu