Premium
O2‐09‐06: TRAJECTORY OF LOBAR ATROPHY IN ASYMPTOMATIC AND SYMPTOMATIC GRN MUTATION CARRIERS: A LONGITUDINAL TBM‐SYN STUDY
Author(s) -
Chen Qin,
Boeve Bradley F.,
Senjem Matthew L.,
Tosakulwong Nirubol,
Lesnick Timothy G.,
Brushaber Danielle,
Dheel Christina,
Fields Julie A.,
Forsberg Leah K.,
Gavrilova Ralitza H.,
Gearhart Debra,
Graff-Radford Jonathan,
Graff-Radford Neill R.,
Jack Clifford R.,
Jones David T.,
Knopman David S.,
Kremers Walter K.,
Lapid Maria I.,
Rademakers Rosa,
Syrjanen Jeremy,
Boxer Adam L.,
Rosen Howard J.,
Wszolek Zbigniew,
Kantarci Kejal
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4504
Subject(s) - atrophy , frontotemporal lobar degeneration , asymptomatic carrier , asymptomatic , temporal lobe , medicine , frontal lobe , parietal lobe , pathology , frontotemporal dementia , dementia , disease , epilepsy , psychiatry
neuropsychology testing and volumetric MRI scans. All participants were at 50% risk of carrying a pathogenic FAD mutation. Standardized uptake value ratios (SUVr) in prespecified regions of interest (ROI) (Braak stages I-VI) were obtained using cerebellar grey matter as the reference region. We compared tau PETaccumulation rates between mutation carriers (MC) and non-carriers (NC). Results: The cohort comprised three NC and sixMC; one symptomatic (Clinical Dementia Rating (CDR) Scale:0.5 and five presymptomatic (CDR:0). MCs were on average 9.2 years younger than their parental age at symptom onset. Presymptomatic MC did not appear to have greater FTP binding or rates of change compared to NC (Figure 1). In one symptomatic MC higher tau signal, and rates of accumulation, were seen across all Braak stage ROIs (Figure 1). Conclusions: Our small cohort could not detect differences in tau accumulation between presymptomatic MC and NC. However, there was widespread and rapid increases in FTP binding (Braak Stage ROIs I-VI) at the time of symptom onset in one MC. Longitudinal tau PET scanning may be useful in tracking progression in mildly symptomatic FAD.