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TD‐P‐13: NOVEL DIGITALIZED MARKERS FOR SCREENING AND DISEASE TRAJECTORY TRACKING IN CLINICAL TRIALS
Author(s) -
König Alexandra,
Narayan Vaibhav,
Aalten Pauline,
Ramakers Inez H.G.B.,
Linz Nicklas,
Tröger Johannes,
Robert Philippe
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4324
Subject(s) - clinical trial , phone , cognition , biobank , computer science , medicine , pathology , bioinformatics , philosophy , linguistics , psychiatry , biology
mild dementia) aged 60 and older. Four computerised (iPAD) neuropsychological assessment instruments (CNAs) will be evaluated: Cogstate, CANTAB, Cambridge Brain Sciences and NIH Toolbox. Participants are randomly assigned to one of two study arms: a 1Month Test-Retest Reliability arm or a Construct Validity arm in which they receive CNAs and a standardised pencil-and-paper (PnP) neuropsychological assessment one week apart and after one year to examine test responsiveness (see Figure). PnP assessment involves 13 standardized tests of complex attention, memory, language, visuospatial processing and executive function, administered in one-to-one assessments. All participants complete an interview to collect medical history, a cognitive screen, a mood scale, a subjective cognitive decline questionnaire, and vision, hearing and manual dexterity testing. They are asked about their experience of each assessment and preference for CNA versus PnP testing. The influence of demographic factors, medical conditions, computer familiarity and attitudes on test performance will be examined. Results: To date, 65 community-living older adults (72.3% female, mean age 72.5 years, mean years education 14.7) have participated; recruitment of clinically-referred participants is underway. 12.3% of community-living participants report not feeling confident about using a computer and 21.5% report limited or no experience with tablets/ipads. Conclusions: CogSCAN is a systematic, comprehensive and independent evaluation of the psychometric properties, acceptability and performance of four prominent computerised neuropsychological assessment instruments within an older adult population.