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IC‐P‐185: SPATIALLY SELECTIVE TAU‐RELATED WHITE‐MATTER PATHWAY ALTERATIONS IDENTIFIED BY A DATA‐DRIVEN APPROACH
Author(s) -
Wen Qiuting,
Risacher Shan L.,
Mustafi Sourajit Mitra,
Harezlak Jaroslaw,
Xie Linhui,
Li Junjie,
West John D.,
Tallman Eileen F.,
Farlow Martin R.,
Unverzagt Fred W.,
Apostolova Liana G.,
Saykin Andrew J.,
Wu Yu-Chien
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4300
Subject(s) - white matter , bootstrapping (finance) , cingulum (brain) , diffusion mri , tractography , psychology , nuclear medicine , neuroscience , magnetic resonance imaging , medicine , artificial intelligence , fractional anisotropy , computer science , mathematics , radiology , econometrics
FTP BPND in amyloid positive individuals[Figure2]. Data collection is still ongoing. Conclusions: Over a two year period, quantitative imaging revealed an increase in tau pathology only in early stage tau pathology regions in SCD subjects. Individuals with higher amyloid load showed relatively higher levels and larger increases in intermediate and late stage tau pathology, supporting the hypothesis that amyloid facilitates the spread of tau pathology.