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IC‐P‐178: SEX DIFFERENCES IN TAU PATHOLOGY ACROSS CORTICAL AND SUBCORTICAL REGIONS OF INTEREST: FINDINGS ACROSS TWO COHORTS
Author(s) -
Scott Matthew R.,
Buckley Rachel F.,
Jacobs Heidi IL.,
Schultz Aaron P.,
Properzi Michael J.,
Mormino Elizabeth C.,
Chhatwal Jasmeer P.,
Johnson Keith A.,
Sperling Reisa A.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4293
Subject(s) - entorhinal cortex , bonferroni correction , alzheimer's disease neuroimaging initiative , apolipoprotein e , psychology , hippocampal formation , supramarginal gyrus , medicine , neuroscience , dementia , disease , functional magnetic resonance imaging , statistics , mathematics
cognitively-normal (CN) and 37 Mild Cognitive Impairment (MCI)/AD Australian Imaging, Biomarkers and Lifestyle (AIBL) Study participants completed F-MK-6240 tau-PET imaging and cognitive evaluation. Tau-PET scans were visually rated on a 4point scale. Figure 1 depicts the rating categories with representative images. Memory functioning and Non-memory functioning composite z-scores were calculated from neuropsychological tests. Regression analyses were used to test the association between NFT subtypes and memory and cognitive performance, adjusting for age, sex, and years of education. Results: Distinct NFT patterns were clearly identified in our cohort. Twelve percent of CN group showed tau tracer binding, mostly limited to MTL (Table 1). This was associated with a one-point decrement on MMSE, but no difference on memory or non-memory functioning, compared to tau Negative CN (Figure 2a-c). In the clinical MCI/AD patients MTL-predominant performed worse on MMSE and Memory functioning, but had preserved Non-memory functioning, compared to the tau Negative group. The Cortical-predominant Group had decrements on MMSE, Memory, and Non-memory functioning, compared to Negative group (Figure 2d-f). Conclusions: NFT pattern subtypes, identified by visual inspection, were identified using F-MK-6240 PET in our cohort of CN and MCI/AD individuals. These subtypes were associated with distinct memory and cognitive functioning. Identification of NFT subtypes may be beneficial for future clinical trials and clinical diagnosis. Longitudinal studies are needed to determine if MTL predominant pattern in clinically impaired patients persists as a distinct subtype of AD or is an earlier stage of disease preceding progressive cortical tau accumulation.